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Main Chapters: 00:00 Intro - Concerta 00:10 Take home message 01:07 What are Osmotic Release Medications? (OROS) 06:08 How does Concerta Work? 09:32 Pharmaceutical Companies and Concerta Generics 12:57 Concerta Shortages Concerta is a slow release form of methylphenidate, that uses an osmotic pumping system for very uniform drug delivery. The manufacturer has stopped making the only truly bioequivalent generic Concerta. The recent shortages of generic versions of Concerta are not directly related to the Adderall shortages that have been a problem for half a year. ----- Free link to my Medium Article on Concerta: https://medium.com/invisible-illness/... Follow / dockruse on Medium for hundreds of full length articles on this subject and more! Access to full Medium articles requires paid membership. ----- References: Development of a new once-a-day formulation of methylphenidate for the treatment of attention-deficit/hyperactivity disorder: proof-of-concept and proof-of-product studies (2003) https://pubmed.ncbi.nlm.nih.gov/12578... J&J buys Alza for $11.8B (2001) https://money.cnn.com/2001/03/26/euro... Bioequivalence Recommendations for CONCERTA (Methylphenidate Hydrochloride) Extended-Release Tablets; Draft Guidance for Industry; Availability (2014) https://www.federalregister.gov/docum... Full Chapter list: 00:00 Intro - Concerta 00:10 Take home message 01:07 What are Osmotic Release Medications? (OROS) 04:05 Comparing Ritalin and Concerta 06:08 How does Concerta Work? 06:57 Difficulties With Making Osmotic Release Medications 08:06 Downsides of Osmotic Release Medications 09:32 Pharmaceutical Companies and Concerta Generics 10:25 Concerta Generics Without Osmotic Release 12:57 Concerta Shortages 16:03 FDA Approvals and Politics 17:51 Outro Streamed live January 18, 2023 ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world. Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background. You're welcome to email him with topics you want discussed, or people you think he should interview. [email protected] #health #mentalhealth #adhd #concerta