Atroposelective Total Synthesis of the Macrocyclic Antibiotic Darobactin A (Baran Group) скачать в хорошем качестве

Atroposelective Total Synthesis of the Macrocyclic Antibiotic Darobactin A (Baran Group)

In this Research Spotlight episode, we're joined by the Baran lab's Darobactin team - Kelly Eberle, Fabian Schneider, and You-Chen Lin - who takes us through their recently published approach to this challenging target. Key reference: J. Am. Chem. Soc. 2022, 144, 14458–14462. https://doi.org/10.1021/jacs.2c05892 Other references (in order of appearance): (Lewis) Nature 2019, 576, 459–464; (Lewis) Nature 2021, 593, 125–129. (Baran) Angew. Chem., Int. Ed. 2017, 56, 11906–11910. (Schreiber) Org. Lett. 2017, 19, 4424–4427. (Reisman) Org. Lett. 2016, 18, 4750–4753. (Sarlah) J. Am. Chem. Soc. 2022, 144, 14026–14030. (Geyer) Chem. Sci. 2019, 10, 8634–8641; for a review on 8-aminoquinoline removal: Chem. Eur. J. 2021, 27, 8411–8436. J. Am. Chem. Soc. 2002, 124, 5288–5290.