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Cesarean Scar Ectopic Pregnancy: A Critical Imaging Diagnosis Every Radiologist Must Recognize Cesarean scar ectopic pregnancy (CSEP) represents a rare but potentially life-threatening complication of prior cesarean delivery, characterized by implantation of the gestational sac within the myometrial defect of a previous hysterotomy scar. With the global rise in cesarean section rates—reaching nearly 50% in some regions—the incidence of CSEP is increasing, although the condition remains underrecognized and frequently underreported. Early and accurate imaging diagnosis is therefore essential to prevent severe maternal morbidity and adverse reproductive outcomes. This presentation highlights the imaging features, diagnostic challenges, and clinical implications of CSEP, emphasizing the central role of early first-trimester ultrasound. Transvaginal ultrasound is the primary diagnostic modality, ideally performed at 6–7 weeks of gestation. Key sonographic findings include a low-lying gestational sac implanted in the anterior lower uterine segment at the site of a previous cesarean scar, thinning of the residual myometrium between the gestational sac and bladder, and abnormal peritrophoblastic vascularity on color Doppler imaging. Measurement of residual myometrial thickness—often less than 2 mm in CSEP—is a critical parameter associated with increased risk of complications. Several diagnostic signs assist in identifying abnormal implantation. The low implantation sign reflects a gestational sac positioned below the midpoint of the uterine cavity, while the crossover sign indicates anterior displacement of the sac relative to the endometrial line, suggesting implantation within the scar niche. Additionally, growth patterns can be classified as endogenic, where the pregnancy expands toward the uterine cavity, or exogenic, where the sac grows outward toward the bladder and abdominal cavity. The exogenic pattern carries a particularly high risk of uterine rupture and progression to placenta accreta spectrum (PAS). Accurate differentiation from other early pregnancy conditions—including cervical ectopic pregnancy, low-lying intrauterine pregnancy, or evolving pregnancy loss—is essential to avoid misdiagnosis. Failure to recognize CSEP can lead to severe complications such as catastrophic hemorrhage, uterine rupture, arteriovenous malformations, or progression to PAS, frequently necessitating hysterectomy and resulting in permanent loss of fertility. Management strategies remain evolving but generally favor early active intervention rather than expectant management due to the high risk of maternal morbidity. Surgical approaches—including ultrasound-guided suction curettage, hysteroscopic or laparoscopic resection, and uterine artery embolization—are commonly employed. Early detection significantly improves outcomes by enabling fertility-preserving treatment before abnormal trophoblastic invasion produces severe vascular complications. Ultimately, the most important preventive strategy is heightened awareness among radiologists. Careful evaluation of gestational sac location in any patient with a history of cesarean delivery, combined with standardized reporting of sac position, growth pattern, residual myometrial thickness, and vascularity, can dramatically reduce missed diagnoses. As imaging criteria continue to evolve and international registries expand available datasets, radiologists play a pivotal role in improving diagnostic accuracy and optimizing patient-centered management of this high-risk condition. APA Citation (7th edition): Kennedy, A., Debbink, M., Griffith, A., Kaiser, J., & Woodward, P. (2024). Cesarean scar ectopic pregnancy: A do-not-miss diagnosis. RadioGraphics, 44(7). Hashtags: #MedicalAI #Radiology #AIBias #MachineLearning #AutomationBias #HealthTech #AIEthics #ObstetricImaging #Ultrasound #MaternalFetalMedicine #EctopicPregnancy #PlacentaAccretaSpectrum #WomenHealth #MedicalImaging #RadiologyEducation #RSNA © 2025 AI Chavelle™ by Jeffrey Chen / SmartRad AI. All rights reserved.