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So what happens after IV iron infusion for restless legs syndrome (RLS)?@andyberkowskimd of ReLACS Health explains how iron infusion is much more efficient than iron supplements and how long it takes for symptoms of RLS to improve. For more details on iron infusion, read his dissertation/blog on the topic of iron infusions: www.relacshealth.com/blog/which-iron-infusion-should-i-choose-for-restless-legs Iron supplements are poorly absorbed, even much less so with food or if taken multiple times per day. Iron infusions go directly into the bloodstream and bypass the gut so there are no issues with absorption from food. Individuals can get months worth of iron supplementation in a matter of minutes through an IV. The effect of the iron infusion on RLS can be immediate, but the effect on symptoms may peak about 6-8 weeks out with continued improvement over that span. The benefits thereafter may last months or more than a year, depending on how much iron is lost from the body after the infusion. Unfortunately, the response to iron infusion varies from person to person. Many get a significant amount of relief from RLS symptoms, others some improvement, while in others it makes no difference. Given the lack of moderate or severe side effects or risks to iron infusion, it is generally worth it, however. IV iron is widely considered a first-line treatment for RLS, even before any medications as it treats an underlying cause of the condition, not just the symptoms. Initially after infusion, the body may use the extra iron in different locations, particularly in the bone marrow to build new red blood cells. The brain may be a low priority for the extra iron, which may not see the most amount of iron from the infusion until 6-8 weeks out. Though iron infusion is rarely enough to combat the effects of augmentation by itself, those with augmentation from dopamine agonists may experience less dopamine withdrawal when tapering off a dopamine agonist with higher iron levels from an infusion; certainly more powerful and faster than waiting 6 months for iron supplements to be absorbed. For more information on the types of iron infusion for RLS, watch this summary: • Types of Iron Infusion for Restless Legs S... If you are looking to understand the ways to increase iron levels for RLS, the this is for you: • How to Increase Iron for Restless Legs Syn... These are the iron levels to consider when it comes to restless legs syndrome, that are much different than for other conditions like anemia: • Iron Levels for Restless Legs Syndrome (RLS) These videos are for general information only, but for those who live in or near Michigan, Ohio, or Florida, you can hire @andyberkowskimd of ReLACS Health for consultation to assess whether you need IV iron, to help manage your RLS, or to address any aspect of your sleep health that needs a little more time and expertise. Go to https://www.relacshealth.com/ for more information.