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#CRAO #EyeStroke #StrokePrevention #VisionLoss #MedicalEmergency #MultidisciplinaryCare #AcuteManagement #SecondaryPrevention #Diagnosis #Treatment Central Retinal Artery Occlusion (CRAO) is an "eye stroke," characterized by sudden, painless vision loss in one eye due to a blocked blood supply. It is a serious medical emergency, demanding immediate, urgent attention similar to a brain stroke. CRAO serves as a critical warning sign, indicating potential blockages elsewhere in the body that could lead to more devastating future strokes. The 2025 protocol provides a roadmap for rapid, coordinated management. Key protocol steps include: **Immediate Diagnosis**: An eye doctor confirms CRAO by examining the retina. Initial conservative measures like eye massage or drops to lower eye pressure may be attempted. **Urgent GCA Screening**: For patients over 50, if Giant Cell Arteritis (GCA) is suspected, immediate high-dose systemic corticosteroids are administered empirically to protect the fellow eye, without waiting for blood test results. **Hyperacute Reperfusion Therapies**: **IV Thrombolysis (clot-buster medicine)**: Can be considered within 4.5 hours, but requires a mandatory brain CT scan beforehand. **Hyperbaric Oxygen Therapy**: May be considered within 24 hours or as salvage therapy. **Urgent Etiologic Workup (Concurrent)**: A parallel search for the underlying cause is initiated. This involves an ultrasound of neck arteries for blockages, detailed heart scans and rhythm monitoring for conditions like atrial fibrillation, and comprehensive blood tests. **Aggressive Secondary Prevention**: This includes antiplatelet medications, high-intensity statins (regardless of baseline cholesterol), and strict control of blood pressure, diabetes, and smoking cessation. **Multidisciplinary Collaboration**: Essential teamwork among ophthalmologists, neurologists, cardiologists, and primary care doctors ensures rapid testing and joint decision-making. The protocol emphasizes rapid response to maximize vision recovery and critically prevent future ischemic events.