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The East African Community (EAC) has made significant strides in the harmonization of medical regulations across its member states, aiming to improve the quality, safety, and efficacy of medicines in the region. Central to this effort is the EAC Medicines Regulatory Harmonization (MRH) initiative, which seeks to establish a unified regulatory framework for the registration of medicines. This pathway is vital for ensuring quicker access to essential medicines, enhancing regulatory efficiency, and fostering regional integration in the healthcare sector. However, as the MRH recommendations are progressively adopted, there are still challenges that the industry faces, particularly in aligning national regulations with regional standards. This industry discussion forum seeks to address these challenges by bringing together key stakeholders from the pharmaceutical industry, regulatory authorities, and healthcare professionals. By discussing the experiences, hurdles, and opportunities encountered in the MRH adoption process, African Pharmaceutical Network aims to create a platform for knowledge exchange and collaborative problem-solving. The adoption of these recommendations is a critical step towards a more integrated, efficient, and transparent regulatory environment, and understanding the nuances of this process is essential for all players involved in the industry.