"The Science of Aging" Impact.Tech Seminar with Martin Borch Jensen скачать в хорошем качестве

"The Science of Aging" Impact.Tech Seminar with Martin Borch Jensen

This seminar on anti-aging was taught by Martin Borch Jensen, the CSO of Gordian Biotechnology. Prior to founding Gordian, he had an extensive career in academic aging research: after a M.S. in nanotechnology, he received Denmark’s most exclusive doctoral fellowship (EliteForsk) for his Ph.D. in biogerontology at the NIH National Institute on Aging/the University of Copenhagen. He then did postdoctoral research at the Buck Institute for Research on Aging, modifying different aging pathways to extend lifespan in model organisms. As a postdoc he received the ~$1M NIH Pathway to Independence award, to start his own research lab. He returned this award to found Gordian, which is building the first truly scalable therapeutic discovery platform for diseases of aging. 0:00 Introduction 3:46 Defining the problem 11:52 Defining aging 22:00 Biological mechanisms of aging 25:00 DNA & RNA 43:45 Proteins 49:05 Metabolism 1:05:00 Senescence & stem cells 1:15:15 Inflammation 1:18:47 Parabiosis 1:22:38 The Longevity Landscape 1:30:36 Challenge 1: Translational path for aging drugs 1:48:00 Challenge 2: Biomarkers of aging 2:15:57 Challenge 3: Optimizing a complex system 2:30:22 Closing Summary