Krebs Cycle Detailed Explanation | MBBS 1st Year | Dr. Anand Mani скачать в хорошем качестве

Krebs Cycle Detailed Explanation | MBBS 1st Year | Dr. Anand Mani

#mbbs1styear #biochemistry #biochemistrynotes #krebscycle Telegram : t.me/doctornext001 MBBS 1st Year : https://anandmani.in/new-courses/26-m... The Krebs Cycle, also known as the Citric Acid Cycle or Tricarboxylic Acid (TCA) Cycle, is a fundamental metabolic pathway that plays a crucial role in cellular respiration. It involves a series of enzyme-catalyzed chemical reactions that generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. Overview of the Krebs Cycle: Location: In eukaryotic cells, the Krebs Cycle occurs in the mitochondrial matrix. In prokaryotic cells, it takes place in the cytoplasm. MICROBIOLOGY INFO Function: The primary purpose of the Krebs Cycle is to produce high-energy electron carriers—NADH and FADH₂—that are utilized in the electron transport chain to generate ATP, the cell's main energy currency. Steps of the Krebs Cycle: Formation of Citrate: Acetyl-CoA (2-carbon molecule) combines with oxaloacetate (4-carbon molecule) to form citrate (6-carbon molecule). This reaction is catalyzed by citrate synthase. BYJU'S Isomerization to Isocitrate: Citrate is rearranged to form isocitrate through the action of the enzyme aconitase. Oxidative Decarboxylation of Isocitrate: Isocitrate is oxidized and decarboxylated to form α-ketoglutarate (5-carbon molecule), producing NADH and releasing CO₂. This step is catalyzed by isocitrate dehydrogenase. Oxidative Decarboxylation of α-Ketoglutarate: α-Ketoglutarate undergoes further oxidation and decarboxylation to form succinyl-CoA (4-carbon molecule), generating another NADH and releasing CO₂. This reaction is catalyzed by α-ketoglutarate dehydrogenase. Conversion to Succinate: Succinyl-CoA is converted to succinate, producing GTP (which can be converted to ATP) in the process. This step is catalyzed by succinyl-CoA synthetase. Oxidation to Fumarate: Succinate is oxidized to fumarate, with the reduction of FAD to FADH₂. This reaction is catalyzed by succinate dehydrogenase. Hydration to Malate: Fumarate is hydrated to form malate, catalyzed by fumarase. Oxidation to Oxaloacetate: Malate is oxidized to regenerate oxaloacetate, producing another NADH. This final step is catalyzed by malate dehydrogenase.