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particle size and shape

particle size is very important parameter of preformulation studies. Powders are likely the least predictable of all materials with respect to flowability. This is because there are a whole lot of factors that can change their flow properties. In tablet formulation, particle size distribution and shape influence mixing efficiency and flow properties of powders and granules. In addition to the effects of particle size distribution and shapes on various physicochemical properties of a drug substance, the biopharmaceutical behaviours of drug substances are equally affected. For instance, the bioavailability of a poorly soluble drug showing a dissolution rate limiting step in the absorption process can be enhanced when administered in a finely divided state rather as a coarse material. Changes in particle size might alter the correlated properties, i.e. shape, surface area, and porosity. This, in turn, can affect bulk properties, product performance, processability, stability and appearance of the end product. The APIs being developed are increasingly more intricate, smaller particle sizes are typically required in the pharmaceutical industry. Therefore monitoring particle size is paramount to the entire development and manufacturing process. Particle shape and particle size distribution, particle surface characteristics also influence the performance and appropriateness of a drug formulation. The link between particle size and product performance is well documented with regards to dissolution, absorption rates, and content uniformity. Reducing particle size can aid in the process of hygroscopicity. Particle size analysis is an integral component of the effort to formulate and manufacture many pharmaceutical dosage forms. Delft Solids Solutions has broad expertise in the area of powder and particle testing and possesses a wide range of analytical instruments and methodologies providing support for product development and insights into mechanistic aspects of particle processes. There are various techniques through which particle size and shape characterization can be done. Laser Diffraction or static light scattering for particle size analyses of dry powders or powders suspended in aqueous or organic liquids Droplet size distributions of sprays, nebulizers, inhalers, etc. Image Analysis – “Seeing is Believing”. Nanoparticle assessment by photon correlation spectroscopy Zeta potential Gravitational Sedimentation Electrical Sensing Zone, highest resolution for narrow size distributions – applicable for cleanliness investigations of liquids and particle concentrations of dispersions. Sieve Analysis, mechanical, dry, wet, and sonic. Morphology (surface and size) by scanning electron microscopy (SEM) coupled to elemental analysis with Energy dispersive X-ray (EDX) #particlesize #particleshape Our social media links 1. Facebook:   / vikas.pandey.399826   2. Twitter:   / drvikaspandey8   3. Research Gate: https://www.researchgate.net/profile/... For Business queries please email at vikasjbpu@gmail.com