Pathology Grand Rounds February 2024- Sponsored by PathSoc & the Jean Shanks Foundation скачать в хорошем качестве

Pathology Grand Rounds February 2024- Sponsored by PathSoc & the Jean Shanks Foundation

SPEAKER- Prof. Joanne Edwards- University of Glasgow "Integrated Technologies For Improved Colorectal Polyp Surveillance" Joanne Edwards is an internationally recognised translational cancer research scientist with a successfully funded portfolio of multi-disciplinary peer-reviewed biomarker research. She has over 200 publications, with over 15,000 citations, an H index of 66, and an established international network of collaborators. She has developed unique patient tissue cohorts with extensive linked clinical data across a breadth of solid tumours from which she has gained an international reputation for expertise in developing biomarkers for personalised patient care. She has a large biomarker research group based in Wolfson Wohl Cancer Research Centre, University of Glasgow and is also Director of the Glasgow Research Tissue Facility, based in Queen Elizabeth Hospital, which works closely with NHSGGC Bio-repository to provide researchers access to a wide variety of human tissue, construction of tissue microarrays, DNA, RNA and access to digital pathology platforms. As theme lead of the colorectal theme for the CRUK Scotland Centre, she aims via collaborations to accelerate translation of research findings to the clinic. Notably, despite being a non-clinical researcher, her work has resulted in her being elected as a highly prestigious Fellow of the Royal College of Pathologists. The work she will be discussing in the current talk is related to her role as Director of the “INtegrated TeChnologies for Improved Polyp SurveillancE” (INCISE) project: a partnership between the University of Glasgow, NHS Greater Glasgow and Clyde, and industry (BioClavis Ltd, Canon Medical Europe, OracleBio). The INCISE collaborative aims to transform bowel cancer screening in the UK by developing a tool that can predict which patients with polyps will go on to develop further polyps. Lastly as Director of Education for the School of Cancer Sciences, she aims to utilise undergraduate, masters and doctoral training programs to inspire the next generation of scientists and researchers. Through the School of Cancer Sciences educational programmes, the aim is to provide a nurturing environment where students learn about the underlying mechanisms of cancer biology, therapeutics and innovative technologies. ABSTRACT: INtegrated TeChnologies for Improved Polyp SurveillancE" Colorectal cancer is 4th most common cancer in UK, with approximately 42,000 new cases diagnosed every year. Through the Scottish Bowel Cancer Screening Programme (SBoSP), NHS Scotland invites everyone aged 50-74 to participate in screening every two years and has driven the early detection of bowel cancer, reducing advanced stage and emergency presentations, with improvement in patient outcomes. However, despite the success SBoSP is far from optimal. Individuals with pre-cancerous polyps that require excision following screening currently require regular follow-up including repeated colonoscopy dependent on the number, size, and dysplasia of excised polyps. Of these individuals only 50% will form further polyps, meaning that many individuals are subjected to an unpleasant, invasive intervention with a small but significant complication risk and at a considerable cost to the NHS (estimated to be £800,000 per annum for procedure cost alone, without inclusion of pathology, lab or admin costs). The INCISE project utilises the latest developments in digital pathology, machine learning and omic techniques to developing a comprehensive real-time risk stratification tool to accurately assess the need for follow-up colonoscopy after polypectomy. We will update you on our progress to date in the current talk.