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Lysergic acid diethylamide (LSD) is one of fungi’s most well known chemical analogues. Today we bring you a leading scientist, Dr. David Nichols who speaks to the history, chemistry, legality and so much more of this notable compound. Topics covered: David Nichol’s career pursuing psychedelic pharmacology Patent litigation, especially with psychedelic constituents Lab testing for new psychedelic analogues in rats Bureaucracy of working with Schedule I substances How to synthesize LSD LSD’s physical characteristics, structure and fluorescence What happens to the LSD molecule when you adjust minute aspects, and what that tells us about itself Structural similarities and differences in an array of psychedelic molecules / chemical ‘templates’ for psychoactive compounds Neuro-mechanics of LSD and other entheogenic compounds Evolution and function of serotonin receptors HPPD: Hallucinogen Persisting Perception Disorder Trepanation: how does it affect neurochemistry, if at all? NBOMes (N-benzyl methoxy): What is it and how does it work? Metabolizing LSD and related compounds Chirality in psychedelics, especially LSD Listener questions Show notes: Hamilton’s Pharmacopeia feat. Dr. Nichols: • Видео Hallucinogens (2004) : https://pubmed.ncbi.nlm.nih.gov/14761... DEA 222 - https://dehs.umn.edu/using-dea-form-2... Mapping the Mind Talk: • From Bench to Bedside: Progress in Psyched... MAPS Talk: • David Nichols, PhD: Psychedelic Neuroscien... Telluride Keynote presentation: • David Nichols - Keynote (2019) Leo Perutz & the Mystery of St Peter’s Snow: https://www.tandfonline.com/doi/abs/1... Trepanation articles & video: https://lostmediawiki.com/Heartbeat_i...) Downloadable literature: https://drive.google.com/drive/folder...