Impact of Renal Function on Iodine-131 Biological Half-Life in Thyroid Cancer Patients скачать в хорошем качестве

Impact of Renal Function on Iodine-131 Biological Half-Life in Thyroid Cancer Patients

Final Masters presentation Impact of Renal Function on Iodine-131 Biological Half-Life in Thyroid Cancer Patients A thesis by: Nazliah Azzahra ABSTRACT 🧠 About this Study: This video summarizes a systematic review and meta-analysis exploring how kidney function, measured by estimated glomerular filtration rate or eGFR, influences the biological half-life of Iodine-131, or I-131, in patients with differentiated thyroid carcinoma, DTC. ⚗️ What We Did: We analyzed data from 13 studies involving 1,811 patients to understand how changes in kidney function impact I-131 clearance. Using meta-regression and pharmacokinetic modeling, we developed an evidence-based dose-adjustment model for radioactive iodine therapy, RAIT. 📊 Key Findings: There is a strong inverse relationship between eGFR and I-131 half-life, with r = -0.678 and p less than 0.001. Patients with lower kidney function retain I-131 much longer. The model suggests reduced I-131 doses of 59–74 percent for patients with moderate kidney impairment, with eGFR between 45 and 59 milliliters per minute per 1.73 square meters. 💡 Why It Matters: Kidney function plays a major role in how quickly the body clears I-131. Adjusting the dose based on eGFR could make radioactive iodine therapy safer and more personalized, helping prevent radiation overdose and reducing risks such as blood toxicity and secondary cancers. 🔬 Towards Precision Medicine: This research supports an eGFR-based dosing strategy — a key step toward more personalized treatment in thyroid cancer care. ========================= For more information visit our: Website: https://www.uwamedicalphysics.org Weblog: http://www.uwamedicalphysics.com Facebook:   / groups   Instagram:   / uwa_medical_physics   LinkedIn:   / medical-physics-uwa-11979b379   Twitter: @MedicalUwa YouTube Channel:    / @medicalphysicsuwa   =========================