Pharmacokinetic Effect of Digoxin and Digitoxin | Difference in Digoxin & Digitoxin | GPAT | NIPER скачать в хорошем качестве

Pharmacokinetic Effect of Digoxin and Digitoxin | Difference in Digoxin & Digitoxin | GPAT | NIPER

Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/de... Book Review Video -    • Text Book of Pharmacology By Prasan R  Bha...   Purchase from Amazon = https://amzn.to/3S0K68h Table of Content https://www.thieme.in/image/catalog/T... Sample Chapter of this book https://www.thieme.in/image/catalog/S... Digoxin and digitoxin are both cardiac glycosides used in the treatment of heart failure and certain arrhythmias. They have similar pharmacological effects but differ in their pharmacokinetic properties, which include absorption, distribution, metabolism, and elimination. Let's explore the pharmacokinetic effects of digoxin and digitoxin: 1. Absorption: Digoxin: Digoxin is well-absorbed from the gastrointestinal tract, with an oral bioavailability of around 70-80%. The rate and extent of absorption can be influenced by food intake and interactions with other medications. Digitoxin: Digitoxin is also absorbed from the gastrointestinal tract, but its absorption is slower and less complete than that of digoxin. It has a higher oral bioavailability of approximately 90-100% due to better absorption. 2. Distribution: Digoxin: Digoxin has a relatively small volume of distribution, meaning it remains predominantly in the blood and does not distribute extensively into tissues. It binds to plasma proteins to a moderate extent (approximately 20-30%). Digitoxin: Digitoxin has a larger volume of distribution compared to digoxin, which allows it to distribute more extensively into tissues. It also binds more strongly to plasma proteins (around 90-95%) than digoxin. 3. Metabolism: Digoxin: Digoxin is primarily metabolized in the liver through processes involving gut flora, and a small portion is metabolized by the liver's cytochrome P450 enzymes. The metabolites formed are less active than the parent drug and are excreted in the urine. Digitoxin: Digitoxin undergoes minimal metabolism in the liver, and most of the administered dose is excreted unchanged in the bile. This characteristic results in a more extended half-life for digitoxin compared to digoxin. 4. Elimination: Digoxin: The elimination of digoxin occurs primarily through the kidneys, where it is excreted unchanged, with only a small percentage being metabolized. The elimination half-life of digoxin is relatively short, averaging around 36-48 hours in individuals with normal kidney function. Digitoxin: Digitoxin is primarily eliminated through the bile and feces, with a small fraction being excreted in the urine. Due to its slow elimination and extensive distribution into tissues, the half-life of digitoxin is significantly longer than that of digoxin, averaging around 5-7 days. Get in touch with the solution by just clicking the following links- Facebook Group-   / solutionpharamcy   Mobile App - https://play.google.com/store/apps/de... New Channel (Pharmacy Dictionary)    / @pharmacydictionary   E-Mail for official and other work - [email protected] #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT