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Are wine, olive oil, and laughter the answer to a long life? Maybe, but probably not. Let’s dig a little deeper. 📜 Write Up - https://zhighley.com/the-island-where... 📸 Instagram - / 🐧 Twitter - / zachhighley 💌 Newsletter - https://zhighley.com/newsletter/ Sources: 1. Deiana L, Ferrucci L, Pes GM, Carru C, Delitala G, Ganau A, Mariotti S, Nieddu A, Pettinato S, Putzu P, Franceschi C, Baggio G. AKEntAnnos. The Sardinia Study of Extreme Longevity. Aging (Milano). 1999 Jun;11(3):142-9. PMID: 10476308. 2. Wu L, Zeng T, Zinellu A, Rubino S, Kelvin DJ, Carru C. A Cross-Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians. mSystems. 2019 Jul 9;4(4):e00325-19. doi: 10.1128/mSystems.00325-19. PMID: 31289141; PMCID: PMC6616150. 3. Marcus, J.H., Posth, C., Ringbauer, H. et al. Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia. Nat Commun 11, 939 (2020). https://doi.org/10.1038/s41467-020-14... 4. Pes GM, Lio D, Carru C, Deiana L, Baggio G, Franceschi C, Ferrucci L, Oliveri F, Scola L, Crivello A, Candore G, Colonna-Romano G, Caruso C. Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians. Aging Clin Exp Res. 2004 Jun;16(3):244-8. doi: 10.1007/BF03327391. PMID: 15462469. 5. Chiang CWK, Marcus JH, Sidore C, Biddanda A, Al-Asadi H, Zoledziewska M, Pitzalis M, Busonero F, Maschio A, Pistis G, Steri M, Angius A, Lohmueller KE, Abecasis GR, Schlessinger D, Cucca F, Novembre J. Genomic history of the Sardinian population. Nat Genet. 2018 Oct;50(10):1426-1434. doi: 10.1038/s41588-018-0215-8. Epub 2018 Sep 17. PMID: 30224645; PMCID: PMC6168346. 6. https://www.nia.nih.gov/news/genetic-... 7. https://www.mortality.org 8. https://www.ncbi.nlm.nih.gov/pmc/arti... 9. https://www.pnas.org/doi/10.1073/pnas... 10. Yang YC, Boen C, Gerken K, Li T, Schorpp K, Harris KM. Social relationships and physiological determinants of longevity across the human life span. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):578-83. doi: 10.1073/pnas.1511085112. Epub 2016 Jan 4. PMID: 26729882; PMCID: PMC4725506. 11. Lee DH, Rezende LFM, Joh HK, Keum N, Ferrari G, Rey-Lopez JP, Rimm EB, Tabung FK, Giovannucci EL. Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults. Circulation. 2022 Aug 16;146(7):523-534. doi: 10.1161/CIRCULATIONAHA.121.058162. Epub 2022 Jul 25. PMID: 35876019; PMCID: PMC9378548. 12. National Research Council (US) Panel on Understanding Divergent Trends in Longevity in High-Income Countries; Crimmins EM, Preston SH, Cohen B, editors. Explaining Divergent Levels of Longevity in High-Income Countries. Washington (DC): National Academies Press (US); 2011. 7, 13. The Role of Health Care. Available from: https://www.ncbi.nlm.nih.gov/books/NB... 14. https://www.unionesarda.it/news/seulo... 15. https://population.un.org/wpp/Downloa... —————————————————————————————————————————————————— Who am I: My name is Zach. I’m a Resident Physician in Boston. I make videos about medical school, studying, and growth. I love trying new things and often mess up. However, every time I screw up, I usually learn something. Whatever I learn, I post it either on YouTube or on my website 🌐 (https://zhighley.com/). I write a weekly newsletter 💌 (https://zhighley.com/newsletter/) linking the best things I read, watched, and listened to that week. Join the 4,000+ that read it every other Sunday morning. The Gear I Use to film videos: https://zhighley.com/resources/#_YouT… What I’m Reading: https://zhighley.com/resources/#_Books