FDA Removes Estrogen Black Box Warning: What Women Need to Know Now скачать в хорошем качестве

FDA Removes Estrogen Black Box Warning: What Women Need to Know Now

The FDA has officially removed the black box warning from estrogen therapy — a major milestone in women’s health. But what does this change actually mean for you? In this video, Amanda Lavecchio, Board‑Certified Nurse Practitioner and co‑founder of Wellness for Life in Anacortes, WA, breaks down: ✔️ What the original 1990s Women’s Health Initiative study got wrong ✔️ Why synthetic hormones led to decades of confusion ✔️ How peer‑reviewed research has repeatedly shown safe, effective benefits of estrogen ✔️ The real risks of low estrogen — including osteoporosis, dementia, UTIs, and cardiovascular disease ✔️ Why timing matters for hormone therapy ✔️ How to understand media headlines vs. scientific evidence If you’re curious about menopause support, hormone optimization, or what this FDA update means for your long‑term health, this video is a must‑watch. 📍 Wellness for Life – Functional Medicine & Aesthetics Serving Anacortes & the greater Skagit County community. Sources: A decrease in estrogen is associated with an increase in all-cause mortality, premature death, and cardiovascular risk: Novella, S., Dantas, A. P., Segarra, G., Medina, P., & Hermenegildo, C. (2012). Vascular aging in women: Is estrogen the fountain of youth? Frontiers in Physiology, 3(165). https://doi.org/10.3389/fphys.2012.00165 Sabbatini, A.R., Kararigas, G.(2020). Estrogen-related mechanisms in sex differences of hypertension and target organ damage. Biology of Sex Differences, 11(31). https://doi.org/10.1186/s13293-020-00... Sarrel, P.M., Njike, V.Y., Vinante, V., Katz, D.L. (2013). The mortality toll of estrogen avoidance: an analysis of excess deaths among hysterectomized women aged 50 to 59 years. American Journal of Public Health, 103(9):1583-1588. https://doi.org//10.2105/AJPH.2013.30... Salpeter, S. R., Walsh, J. M., Greyber, E., Ormiston, T. M., & Salpeter, E. E. (2004). Mortality associated with hormone replacement therapy in younger and older women: a meta-analysis. Journal of General Internal Medicine, 19(7), 791–804. https://doi.org/10.1111/j.1525-1497.2... A decrease in estrogen is associated with an increased risk of osteoporosis. Cheng, C. H., Chen, L. R., & Chen, K. H. (2022). Osteoporosis due to hormone imbalance: An overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover. International Journal of Molecular Sciences, 23(3), 1376. https://doi.org/10.3390/ijms23031376 Ji, M. X., & Yu, Q. (2015). Primary osteoporosis in postmenopausal women. Chronic Diseases and Translational Medicine, 1(1), 9–13. https://doi.org/10.1016/j.cdtm.2015.0... A decrease in estrogen is associated with an increase in insulin resistance. Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., Han, G., Newell-Fugate, A., Tian, Y., Majeti, R., Liu, W., Xu, Y., Wu, C., Allred, K., Allred, C., Sun, Y., & Guo, S. (2019). Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor foxo1. Diabetes, 68(2), 291–304. https://doi.org/10.2337/db18-0638 Gupte, A. A., Pownall, H. J., & Hamilton, D. J. (2015). Estrogen: an emerging regulator of insulin action and mitochondrial function. Journal of Diabetes Research, 2015(916585). https://doi.org/10.1155/2015/916585 A decrease in estrogen is associated with degenerative as well as refractive ocular disease. Korpole, N. R., Kurada, P., & Korpole, M. R. (2022). Gender difference in ocular diseases, risk factors and management with specific reference to role of sex steroid hormones. Journal of Mid-life Health, 13(1), 20–25. https://doi.org/10.4103/jmh.jmh_28_22 Alcohol interferes with the body’s ability to detoxify estrogen and increases the risk of breast cancer: Scoccianti, C., Lauby-Secretan, B., Bello, P. Y., Chajes, V., & Romieu, I. (2014). Female breast cancer and alcohol consumption: a review of the literature. American Journal of Preventive Medicine, 46(3 Suppl 1), 16–25. https://doi.org/10.1016/j.amepre.2013... Scoccianti, C., Straif, K., & Romieu, I. (2013). Recent evidence on alcohol and cancer epidemiology. Future Oncology (London, England), 9(9), 1315–1322. https://doi.org/10.2217/fon.13.94 Transdermal delivery of estrogen is more effective in lowering blood pressure then oral delivery: Ashraf, M. S., & Vongpatanasin, W. (2006). Estrogen and hypertension. Current Hypertension Reports, 8(5), 368–376. https://doi.org/10.1007/s11906-006-00... Iorga, A., Cunningham, C. M., Moazeni, S., Ruffenach, G., Umar, S., & Eghbali, M. (2017). The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biology of Sex Differences, 8(1), 33. https://doi.org/10.1186/s13293-017-01... [This video is for educational purposes only and not medical advice. Please consult your healthcare provider.]