Do Psychedelics Work Through Presynaptic 5-HT2A Receptors? скачать в хорошем качестве

Do Psychedelics Work Through Presynaptic 5-HT2A Receptors?

In this episode of Targeted Neuro Talks, Dr. Omar J. Ahmed (University of Michigan), Associate Professor of Psychology, Neuroscience, and Biomedical Engineering, joins Dr. Sam Banister, CSO of Xylo Bio, to discuss his lab’s cutting-edge work uncovering the neural circuit mechanisms underlying psychedelic therapeutics. Key topics include: • Evidence that psychedelic therapeutic effects depend on presynaptic—not just postsynaptic—5-HT2A receptors • Why psychedelics may influence up to 75–90% of neurons despite limited receptor expression • Using highly selective compounds like 25CN-NBOH to disentangle psychedelic polypharmacology • New findings showing psychedelics suppress neuronal excitability via potassium channels References: • Dr. Ahmed's recent publication: https://www.nature.com/articles/s4138... • Dr. Ahmed's mentioned preprint: https://www.biorxiv.org/content/10.11... • For a complete list of Dr. Ahmed's works and research interests: https://www.omarlab.org/ Targeted Neuro Talks is Xylo Bio’s thought leadership series spotlighting insights from experts shaping the future of neurotherapeutics. Learn more at www.xylo.bio