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This Vein and Lymphatic University Grand Rounds session reviews the causes, clinical significance, and management of saphenous vein recanalization after endovenous treatment. Professor Ed Mackey (USA) presents available evidence, guideline recommendations, and practical strategies, followed by expert discussion on challenging scenarios, including anterior saphenous vein reflux and recanalization after cyanoacrylate closure. Key learning points: • Recanalization alone does not mandate treatment; management should focus on symptomatic recurrence confirmed by duplex ultrasound. • Endovenous thermal ablation remains the preferred option for symptomatic truncal vein recanalization when catheter access is feasible, with foam sclerotherapy and phlebectomy playing key adjunctive roles. • The anterior saphenous vein is a common source of recurrence, and treatment decisions should be individualized based on reflux, vein size, and symptoms. • Management of recanalization after glue ablation remains an area of uncertainty, with limited data and evolving clinical practice. This session highlights the importance of tailored, anatomy-driven treatment in the absence of robust randomized data.