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📌 Simultaneous Liver–Kidney Transplantation (SLKT/CLKT) represents one of the most complex procedures in modern transplantation medicine. This video provides a comprehensive, anesthesia-focused review of real clinical cases and evidence-based perioperative guidelines for SLKT. ________________________________________ 🔹 Part 1. Case Presentation – Practical Anesthetic Strategies from Real Cases 🏥 Case 1. ADPKD Kidney & Liver Transplantation • Combined renal and hepatic involvement in Autosomal Dominant Polycystic Kidney Disease (ADPKD) • Preoperative assessment: clinical presentation, laboratory findings, liver and renal function, electrolytes, and clinical scoring systems • Surgical planning and key anesthetic decision-making • Intraoperative course and management Case 2. Hepatorenal Syndrome (HRS) • Clinical background and significance of HRS • Preoperative patient evaluation • Anesthetic and monitoring strategies • Phased fluid and hemodynamic management 💧📈 • Role of intraoperative renal replacement therapy (RRT) ________________________________________ 🔹 Part 2. Clinical Guideline – Core Principles of Anesthetic Management for CLKT 📘 • Rationale and pathophysiologic basis for CLKT • Hepatorenal Syndrome: comparison of old vs. new diagnostic criteria (table) and explanation of Stages 1–3 • ADPKD-specific considerations: mass effect, vascular complications, and surgical implications • Key anesthetic pharmacologic considerations in CLKT (table) 💊 • Phase-based intraoperative hemodynamic goals with preload and afterload strategies (table) • Principles of intraoperative RRT/CRRT and comparison of CRRT modalities ⚙️ ________________________________________ 🔹 Part 3. Comprehensive Review – Current Evidence on Adult SLKT 📊 • The rise of SLKT and its evolving clinical landscape • Etiologies and pathophysiology of concurrent liver and kidney failure • HRS pathophysiology and comparison of historical vs. updated classifications • The SLKT vs. liver transplant alone (LTA) dilemma • OPTN “Safety Net” policy and its clinical implications • Comparative analysis of patient survival, graft survival, and post-transplant renal outcomes • Prognostic factors influencing survival in SLKT and dual-listed patients • Anesthetic considerations and perioperative implications • Pharmacokinetic impact of anesthetic agents in SLKT (table) • Strategic role of intraoperative renal replacement therapy (IORRT) ________________________________________ 🎯 This video is intended for • Anesthesiologists and trainees involved in liver and kidney transplantation • Clinicians managing patients with advanced hepatic and renal failure • Healthcare professionals seeking a structured, evidence-based approach to SLKT perioperative management 👍 If you find this content helpful, please like, subscribe, and turn on notifications! ________________________________________ 🔖 #SimultaneousLiverKidneyTransplantation #SLKT #CLKT #TransplantAnesthesia #Anesthesia #HepatorenalSyndrome #HRS #ADPKD #IORRT #CRRT #LiverTransplant #KidneyTransplant #PerioperativeMedicine #HemodynamicManagement #CaseReport #ClinicalGuideline #AnesthesiaEducation