McGill (iGEM 2023 Finalist Presentation) - Undergrad Grand Prize Winner скачать в хорошем качестве

McGill (iGEM 2023 Finalist Presentation) - Undergrad Grand Prize Winner

Video from the 2023 iGEM Grand Jamboree: https://jamboree.igem.org/2023 Proteus - A programmable and modular oncogene targeting and pyroptosis inducing system Prevalence of cancer has been on the rise in the last twenty years, with cancers like pancreatic cancer still not improving in terms of treatment options. We engineered a novel, personalized therapeutic technique. A personalized treatment modality restricts negative off-target effects, ideally killing cancerous cells before surgical resection becomes the only viable treatment. We utilize the newly discovered CRISPR system, Craspase, to engineer forced pyroptotic cell death among cancerous cells. Craspase is a CRISPR RNA-guided, RNA activated protease, which mediates our personalized therapeutic approach. Our team takes advantage of the high homogeneity of KRAS mutations in pancreatic cancer to design a genetic-level therapeutic that targets the cancer at its root, rather than targeting hallmarks of cancer. We designed modular parts for our project in hopes of engineering a novel therapeutic for many different manifestations of cancer, and perhaps more generally any disease propagating through RNA.