TUIT Estonia (iGEM 2023 Finalist Presentation) - Overgrad Grand Prize Winner скачать в хорошем качестве

TUIT Estonia (iGEM 2023 Finalist Presentation) - Overgrad Grand Prize Winner

Video from: iGEM 2023 Grand Jamboree Final Day Show: https://jamboree.igem.org/2023 BeeYeast: Yeast Engineering to Fight Bee Viral Infections Honey bees play a crucial role as pollinators that is essential for preserving biodiversity. They also yield valuable products such as honey and beeswax, integral to human livelihoods. Unfortunately, honey bee populations are globally declining, influenced by factors like pathogens, climate shifts, and excessive pesticide use. Among these challenges, the Deformed wing virus (DWV), primarily transmitted by mites, is particularly widespread and detrimental, causing the death of millions of bees annually. The Estonia-TUIT team aims to suppress viral protein expression within bee cells by inducing RNA interference response. Our strategy involves genetically modified yeast cells producing short hairpin RNAs, which inhibit DWV gene expression. To deliver these shRNAs into bee cells, we intend to either feed our modified yeast to bees or directly inject shRNA-containing extracts into honeycombs. This approach aims to boost the bee's inherent RNA interference immune response, protecting them from the virus's harmful effects.