Identifying and Managing Respiratory Diseases and Symptoms after Transplant скачать в хорошем качестве

Identifying and Managing Respiratory Diseases and Symptoms after Transplant

Summary: Stem cell transplant recipients may be at risk for pulmonary complications including graft-versus-host-disease after transplant. This presentation describes the symptoms and treatments for these complications with particular attention to bronchiolitis obliterans syndrome. Presenter: Kyle Brownback MD, FCCP, University of Kansas Medical Center To read the transcript, go to: https://www.bmtinfonet.org/video/iden... Highlights: Four major pulmonary issues can arise for transplant patients: pre-existing pulmonary conditions that compromise lung function, infections arising after transplant, drug toxicity and side effects, and GVHD that affect the lungs. Bronchiolitis obliterans syndrome is a type of graft-versus-host-disease (GVHD) in which the bronchioles of the lung become narrowed and compromise breathing. Treatment for bronchiolitis obliterans syndrome includes systemic and inhaled steroids. They can be essential to treatment but have serious side effects. Transplant patients can reduce the risk of developing serious lung and breathing problems by getting treated for asthma or COPD, quitting smoking, avoiding vaping, and using air purifiers. Wearing masks, maintaining hand hygiene and other precautions to avoid infection, along with physical activity can minimize the effects of post-transplant pulmonary issues and GVHD. April 2023, Part of the Virtual Celebrating a Second Chance at Life Survivorship Symposium Presentation is 38 minutes long with 22minutes of Q & A Key Points: (00:02:00): The lungs are an ingenious system by which we're able to bring oxygen from our environment into our body so it can be used by our cells, and also expel our waste gas, which is carbon dioxide. (00:05:32): A variety of tests are used to test patients for bronchiolitis obliterans including spirometry, tests for lung volume and diffusion capacity, and tests forforced vital capacity compared to actual lung function. (00:12:53): Prior to transplant, patients are typically tested for pre-existing lung conditions such as asthma, COPD, interstitial lung disease, and long COVID. (00:14:24): Pulmonary infections from various sources including bacterial, fungal, viral, pneumocystis, cytomegalovirus, aspergillus and respiratory syncytial virus (RSV) can pose pulmonary risks for transplant patients. (00:16:40): The conditioning regimen given prior to transplant as well as some medications, like checkpoint inhibitors, can create pulmonary problems for transplant patients. Typically, these patients present with symptoms similar to a lot of other infections. (00:18:19): There are three major forms of GVHD that affect the lungs: idiopathic pneumonia syndrome, organizing pneumonia and is bronchiolitis obliterans syndrome (BOS) (00:18:40): Idiopathic pneumonia syndrome may or may not be an actual manifestation graft-versus-host disease. (00:19:38): Organizing pneumonia is a pneumonia that can occur in patients and is not infectious. This is a pneumonia that is not treated with antibiotics. It was very common with COVID and is treated with steroids. (00:24:03): Bronchiolitis obliterans syndrome is diagnosed by the presence of other forms of GVHD and signs of airflow obstruction. (00:29:34): Pulmonary rehabilitation is a supervised exercise regimen that can be crucial in restoring lung infection. Meet the speaker: https://www.kumc.edu/kbrownback.html WHO WE ARE: BMT InfoNet is dedicated to providing patients and their loved ones with emotional support and high quality, easy-to-understand information about blood stem cell transplants (bone marrow, peripheral blood and cord blood) and other cellular therapies. Whether you are just beginning your transplant or cellular therapy journey, or learning to manage the joys and challenges of survivorship, BMT InfoNet is here to help before, during and after treatment. Our goal is to empower you with credible information and emotional support, so that you can take a more active role in decisions affecting your health. http://www.bmtinfonet.org VISIT US ON SOCIAL MEDIA:   / bmtinfonet     / bonemarrowstemcelltransplantclub     / bmtinfonet     / bmtinfonet     / bmt-infonet