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IUI that is Intra Uterine Insemination has a success rate of about 10 – 15 % per cycle based upon the clinical condition for which we are doing the procedure. In good selected cases, the IUI in over the last 3 – 4 cycles, has got a good success rate of about 30 -40 % cumulative success rate, that is the success rate over the last 2 -3 cycles. But per cycle success rate is roughly about 10 – 15%. If a careful selection of the couple is done, and if the necessary factors are evaluated properly, IUI has got a good success rate in about the recommended conditions like mild to male factor infertility, unexplained infertility and mild to moderate endometriosis. At the same time, IUI is also done in for couples, where donor sperm is necessitated, where we do a Intra Uterine Insemination with the donor sperm. In these cases, the success rate is roughly about 20 – 30 % per cycle because the sperm parameters are very good. This procedure is also done for couples wherein there is sero discordancy by which one of the partner can be a sero positive patient, which is having some infections like HIV etc and the other partner is negative. So by doing this technique, we can reduce the transmission of infection from one partner to another.