Photosensitive natural peptides for the optical control of ion channels - Michel de Waard скачать в хорошем качестве

Photosensitive natural peptides for the optical control of ion channels - Michel de Waard

Photopharmacology enables selective modulation of compound potency within specific organs in vivo. Unlike optogenetics, it holds greater clinical promise as it often avoids genetic tissue manipulation. We will present technologies applied to natural peptides active on ion channels, where Nanion’s SyncroPatch 384 proves highly valuable. These peptides offer key advantages: high affinity, in vivo stability, targeted ion channel interaction, and slower tissue diffusion than small molecules. The goal is to assess these technologies directly in vivo for controlling physiological parameters or tissue excitability. The talk will highlight their implementation, versatility, and clinical potential. Visit us at www.nanion.de to learn more about the SyncroPatch 384!