Generative AI and the Secrets of Your Immune System | Research Roundtable with Dr. Jim Heath скачать в хорошем качестве

Generative AI and the Secrets of Your Immune System | Research Roundtable with Dr. Jim Heath

In this compelling Research Roundtable talk, ISB President and Professor Dr. Jim Heath explores how generative AI is revolutionizing our understanding of the human immune system. Dr. Heath introduces TARPON, a novel AI model that can generate realistic T cell receptors (TCRs) based on sequence data and patient metadata — shedding new light on the diversity of human immunity across aging, cancer, infectious disease, and chronic illness. By analyzing over 1 million TCRs, TARPON reveals immune “rule sets” shaped in the fetal thymus and shows how these rules can break down in adults — with significant implications for disease severity, especially in older men facing infections like COVID-19. Watch to learn how AI is helping decode immune function, predict disease outcomes, and identify potential pathways for next-generation therapies. Learn more about the Institute for Systems Biology: https://isbscience.org Topics covered: T cells and immune system diversity Why mouse models fall short for human immunology How generative AI models like TARPON work Rule violations in immune development AI-driven insights into COVID-19 severity Future directions for AI and systems biology