Calcineurin Inhibitors | Pharmacology скачать в хорошем качестве

Calcineurin Inhibitors | Pharmacology

This short-animated clip is the illustration of Calcineurin inhibitors. It explains the calcineurin inhibitors' mechanism of action and calcineurin pathway. Calcineurin inhibitors are immunosuppressants that inhibit the action of calcineurin. ▬ 📌 Calcineurin Inhibitors Calcineurin is an enzyme that activates T-cells of the immune system. This class includes 🟠 Cyclosporin 🟠 Voclosporin 🟠 Pimecrolimus and Tacrolimus In a normal person, when an antigen binds to T-cell receptors it activates phospholipase C. This causes the release of Calcium. A high level of Calcium activates calcineurin. Calcineurin with immunophilin causes dephosphorylation of NFAT (Nuclear factor of activated T-cells). NFAT is responsible for the upregulation of cytokines genes and transcription of Interleukin 2 which is the T-cell growth factor. Calcineurin inhibitors inhibit Calcineurin and Immunophilin. This prevents dephosphorylation of NFAT and IL-2 transcription. ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻‍⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More