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Chapters 00:00 - Case Presentation and Question 05:09 - Correct Answer Revealed and Explanation A 103-year-old woman with severe, heterogeneous emphysema and recent one-way endobronchial valve placement continues to experience persistent exertional dyspnea and minimal functional improvement at follow-up. High-resolution CT shows incomplete fissure between lobes, and serial testing reveals unsatisfactory lobar volume reduction. What anatomic and physiologic clues in her presentation can help explain her ongoing symptoms and point to the next management step? VIDEO INFO Category: Pulmonary Anatomy, Human Anatomy, USMLE Step 1 Difficulty: Hard - Advanced level - Challenges experienced practitioners Question Type: Treatment Failure Case Type: Routine Visit - Standard clinical encounter in outpatient setting Watch the video for explanation, or see the full explanation at: https://endlessmedical.academy/auth?h... QUESTION A 103-year-old woman presents for a scheduled pulmonary clinic follow-up 8 months after bronchoscopic lung volume reduction using one-way endobronchial valves for severe, heterogeneous emphysema predominantly in the right upper lobe. She lives independently and is a retired teacher. She is a former smoker (2 packs/day for 25 years; quit 3 years ago). She reports persistent exertional dyspnea without improvement in 6-minute walk distance and occasional bloating after processed foods.... OPTIONS A. Confirm interlobar collateral ventilation with CT fissure scoring plus Chartis, then pursue fissure completion and staged valve re-implantation B. Empirically upsize and add segmental endobronchial valves in the same lobe without collateral-ventilation testing or fissure assessment C. Switch the target to right middle lobe valve placement based on symptoms alone, deferring collateral-ventilation testing and fissure analysis D. Place endobronchial coils in the target lobe immediately as an alternative, without addressing the interlobar fissure or testing for collateral ventilation Further reading: [1] Bronchoscopic Lung Volume Reduction with Endobronchial Valves: Consensus on Patient Selection and Periprocedural Management Authors: Wahidi MM, Lentz RJ, Criner GJ, et al. Year: 2025. Type: Guideline. Educational value: Clarifies anatomical selection criteria (fissure completeness, target lobe) and periprocedural steps for BLVR. Confidence of existence and relevancy: 100% Available at: https://pubmed.ncbi.nlm.nih.gov/40952... [2] Predicting Lung Volume Reduction after Endobronchial Valve Therapy Is Maximized Using a Combination of Diagnostic Tools Authors: Koster TD, van Rikxoort E, Huebner R-H, et al. Respiration. Year: 2016. Type: Study. Educational value: Highlights importance of anatomical assessment (fissure integrity, collateral ventilation) to optimize candidate selection. Confidence of existence and relevancy: 100% Available at: https://pubmed.ncbi.nlm.nih.gov/27577... Links to sources are provided for optional further reading only. The questions and explanations are independently authored and do not reproduce or adapt any specific third-party text or content. --------------------------------------------------- Our cases and questions come from the https://EndlessMedical.Academy quiz engine - multi-model platform. Each question and explanation is forged by consensus between multiple top AI models (i.e. Open AI GPT, Claude, Grok, etc.), with automated web searches for the latest research and verified references. Calculations (e.g. eGFR, dosages) are checked via code execution to eliminate errors, and all references are reviewed by several AIs to minimize hallucinations. Important note: This material is entirely AI-generated and has not been verified by human experts; despite stringent consensus checks, perfect accuracy cannot be guaranteed. Exercise caution - always corroborate the content with trusted references or qualified professionals, and never apply information from this content to patient care or clinical decisions without independent verification. Clinicians already rely on AI and online tools - myself included - so treat this content as an additional focused aid, not a replacement for proper medical education. Visit https://endlessmedical.academy for more AI-supported resources and cases. This material can not be treated as medical advice. May contain errors. --------------------------------------------------- #AABIP AABIPTM is a trademark of the American Association for Bronchology and Interventional Pulmonology (AABIP). The Interventional Pulmonology Board Certification Examination is administered by AABIP. AABIP does not endorse this publication. This publication and EndlessMedical LLC have no connection or association with AABIP.