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Thank you to our generous sponsors, Mitsubishi Tanabe Pharma America, Amylx Pharmaceuticals, and Numotion for making this event possible. TDP-43 protein buildup is a common factor in nerve cell damage and is found in the brains of people with ALS and ALS/FTD. We've developed two mouse models to study this: one for inherited ALS and another for non-inherited cases. Our goal is to figure out how TDP-43 buildup leads to the breakdown of upper motor neurons by examining it at the cellular and molecular levels. Hande Özdinler, PhD, is an associate professor of neurology (neuromuscular disease) at the Northwestern University Feinberg School of Medicine. She is a faculty member at the Les Turner ALS Center, Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Robert H. Lurie Comprehensive Cancer Research Center, and Chemistry of Life Processes Institute at Northwestern University. Dr. Ozdinler’s research aims to understand the cellular and molecular mechanisms responsible for selective vulnerability and progressive degeneration, with special interest in upper motor neurons. The Özdinler lab is currently working towards developing drug discovery platforms that incorporate upper motor neuron health as a read-out, and towards the identification of target engagement and pharmacokinetic biomarkers that can be utilized in the upcoming clinical trials, including patients with upper motor neuron loss.