DNA Encoded Chemical Library at HitGen: Principle, Practice and Application скачать в хорошем качестве

DNA Encoded Chemical Library at HitGen: Principle, Practice and Application

Chemspace & HitGen held the Webinar 'DNA-Encoded Chemical Library at HitGen: Principle, Practice and Application', which took place on 15th of October, 2020. DNA-encoded chemical library (DECL) is an innovative drug discovery technology rapidly gaining widespread interest in the pharmaceutical industry in recent years. It combines the power of molecular biology, combinatorial chemistry, high-throughput screening, and advanced informatics to create vast number of novel molecules for hit identification and lead generation. As one of the major leading companies in this area, HitGen has established an industry-leading platform for early-stage drug discovery research centered on DECLs. This webinar covers the principle, practice and application of DNA-encoded library technology with proven successes in the selection of various target classes. The webinar finally concludes with the presentation of HitGen’s commercially available off-the-shelf DNA-encoded chemical library for self-service screening. Now Chemspace offers you OpenDEL®, a self-serve product from HitGen Inc. OpenDEL® has been first released by HitGen Inc. in 2015. After several years of evolution, it now contains 2 subsets of libraries: small molecule DELs and macrocyclic DELs. Discover sets now! https://bit.ly/354zPQ8 #Chemspace #HitGen #DEL 0:00 General info about webinar rules 0:59 Chemspace introduction by CEO Yurii Moroz. 4:28 Speaker’s introduction: Dr. Guansai Liu, Senior Director of Chemistry of HitGen. 6:11 Here we go! 6:57 Disclaimer 7:17 Outline of the presentation: 8:44 Budget on R&D and the cost to launch drugs 10:02 Opportunities from human Genome 11:24 Chemical Space 12:25 Major approaches to small molecule Drug Discovery 13:23 Invention and advance of DNA-encoded library 14:44 DNA-encoded library technology as a powerful tool 15:44 Basic construct of a DEL compound 17:33 DEL construction via "Split-and-Pool" 19:59 Hit identification process by DEL affinity selection 23:01 Reported active compounds generated from DELs 24:53 DNA-encoded chemical library design strategies at HitGen 28:51 On-DNA chemistry toolbox 30:16 Examples of on-DNA chemistry development 31:42 Examples of introducing key scaffolds into DECLs 33:35 From aqueous reaction systems to pure organic systems 34:29 DEL products at HitGen (more 500 Bn Cmpds) 37:51 Topological shape analysis of HitGen small molecular DEL compounds 38:45 Analysis of molecular shape diversity from exemplified small molecular DELs 39:54 DEL screening statistics at HitGen 41:35 Identification of transferase inhibitors 43:03 Identification of selective ROCK2 inhibitors 44:11 Identification of IL-17A/IL-17R blockers 45:43 Identification of RNA Helicase inhibitors 47:31 Novel GPCR inhibitor discovery 48:12 Identification of protein degraders 49:58 Hit expansion by DELT 51:07 Identification of novel EGFR T790M covalent inhibitors 51:54 HitGen overview 52:37 Development history 53:18 Integrated Drug Discovery Platform at HitGen 53:41 HitGen’s pipelines 53:58 Flexible business model creating value for partners 54:26 Custom DEL products provided by HitGen 55:03 DEL-related Service and Products 55:30 OpenDEL® as off-the-shelf products for self-service screening 58:40 Q&A session