Pathology Grand Rounds March 2024- Sponsored by PathSoc & the Jean Shanks Foundation скачать в хорошем качестве

Pathology Grand Rounds March 2024- Sponsored by PathSoc & the Jean Shanks Foundation

SPEAKER- Professor Tom Jacques- UCL/Great Ormond Street Hospital "The Cell Biology of Developmental Tumours: Evidence from Childhood Brain Tumours" Tom is Professor of Paediatric Neuropathology at the UCL Great Ormond Street Institute of Child Health and the Clinical Lead/Laboratory Director for the Department of Histopathology at Great Ormond Street Hospital for Children. He runs a research programme focussed on paediatric brain tumours and epilepsy. He is Editor in Chief of Neuropathology and Applied Neurobiology, an editor of the recently published WHO Classification of Childhood Tumours, and an editor of the 10th edition of Greenfield’s Neuropathology. He is a member of cIMPACT‐NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy and was the national lead for the Childhood Solid Tumour domain of the Genomics England Clinical Interpretation Partnership. ABSTRACT: "The Cell Biology of Developmental Tumours: Evidence from Childhood Brain Tumours" Childhood tumours have unique biological differences from typical adult-onset tumours, arising in the complex cellular milieu of developing organs and often driven by only one or a few oncogenic variants. Furthermore, many present as chronic diseases requiring long-term treatment, and we understand little about the long-term changes in biology that occur during their natural course, let alone after prolonged targeted therapies. The work in my laboratory aims to understand the cellular and genomic complexity of childhood tumours, and how these tumours change with time, by focussing on the particular challenges posed by brain tumours. Brain tumours are the most common solid tumour in children and the most common cancer-related cause of death in children. However, children who survive carry a significant risk of life-long, life-altering disability. While some children have immediately life-threatening malignant brain tumours, many do experience their tumours as a chronic disease complicated by neurological impairments and severe epilepsy over many years and are increasingly receiving extended periods of treatment with targeted therapies.