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Pharmocotypes within the schizophrenias

Pharmocotypes with in the schizophrenias This lecture introduces the concept of ‘pharmacotype.’ Pharmacotype is a word I coined to describe a subtype of illness that can be defined based on its pattern of medication response. I’ll argue that there are at least 4 (possibly 5) distinct pharmacotypes within the modern diagnosis of schizophrenia. The most common pharmacotype should be called ‘dopamine psychosis’ since it is defined by rapid and robust response to drugs that turn down the brain’s dopamine signals. Other pharmacotypes will probably eventually map to ‘inflammatory psychosis’ and to ‘glutamate psychosis.’ These pharmacotypes are characterized, in part, by poor response to dopamine-regulating treatments. They respond better to other types of care. This lecture is part of Northeast Ohio University's education(+)consultation service, SZconsult. A powerpoint file for this lecture is available at http://szconsult.org/ TIMESTAMPS 00:00 - Intro 00:14 - Pharmocotypes with in the schizophrenias 01:25 - I love drugs 03:13 - Pathophysiology 03:54 - Scenario 1 05:08 - Treatment resistant CDHD 06:21 - Scenario 2 07:02 - Pharmocotypes are abundant in medicine 09:18 - schizophrenia as a heterogeneous group of disorders 09:37 - Conceptual pedigree favours heterogeneity 10:11 - Divergent clinical course 12:12 - If schizophrenia was discovered today 15:05 - Pharmocotypes within the schizophrenias 16:00 - Dopamine biomakers 16:14 - Two illness based on dopamine metabolite levels 16:45 - Two illness based on dopamine synapse density 17:13 - Two illness based on dopamine receptor density 17:35 - Two illness based on PET scan dopamine synthesis capacity 18:36 - Summary ⏳ Related Videos ⏳    • Do antidepressants reduce self harm?      • Medications to help stop smoking | Ask A P...      • Alcoholism Medications and How They Work      • Does cannabis use affect bipolar disorder ...      • What Is Schizoaffective Disorder?   I also have a Podcast “Ask A Psychiatrist” that is available on Google, Apple or Spotify. Click here ⬇️ for more information about the podcast: https://askapsychiatrist.info ABOUT ME: I’m a board-certified psychiatric physician and also have a PhD in pharmacology. I’m a consultant psychiatrist, researcher, lecturer, teacher, and solution-focused scholar currently affiliated with Northeast Ohio Medical University Ask A Psychiatrist