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Watch the Full Video at https://www.jove.com/v/2252/assaying-.... Assaying β-amyloid Toxicity using a Transgenic C. elegans Model - a 2 minute Preview of the Experimental Protocol Vishantie Dostal, Christopher D. Link University of Colorado, Institute for Behavioral Genetics; University of Colorado, Integrative Physiology; The intensely studied nematode worm Caenorhabditis elegans can be transgenically engineered to express the human β-amyloid peptide (Aβ). Induced expression of Aβ in C. elegans muscle leads to a rapid, reproducible paralysis phenotype that can be used to monitor treatments that modulate Aβ toxicity. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments