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This module reviews the underlying mechanisms of diabetes, including the etiology and types of diabetes, the impact of elevated blood glucose on the body, and the development of long-term complications. It also covers diagnostic criteria, glycemic targets, and the importance of individualized treatment strategies to improve patient outcomes. Learning Objectives By the end of this module, learners will be able to: Explain the pathophysiology of type 1 and type 2 diabetes and how insulin dysfunction affects glucose uptake in cells. Identify the short-term and long-term complications associated with uncontrolled diabetes and their physiological basis. Describe the diagnostic criteria for diabetes in Canada and how early detection can preserve beta-cell function. Interpret recommended glycemic targets for various patient populations, including adjustments for elderly or palliative care patients. Evaluate evidence from key clinical trials (UKPDS, ADVANCE) regarding the benefits of glycemic control on morbidity and mortality.