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In this powerful 21-minute lecture, Dr. William Li explains why OMAD (One Meal A Day) is not just about fasting — it’s about timing. Most people focus on what to eat, but the real metabolic advantage comes from aligning your meal with your circadian rhythm. Your hormones, insulin sensitivity, digestion, and even sleep quality all change throughout the day — and that determines how effective OMAD really is. In this video, you’ll learn the science behind morning, afternoon, and evening OMAD… how each affects fat burning, autophagy, energy levels, and sleep… and how to find the timing that works best for your biology and lifestyle. You’ll also discover a simple 2-week testing framework to identify your ideal OMAD window scientifically — not emotionally. If you want better fat loss, stable energy, improved sleep, and real metabolic flexibility… this lecture will change how you think about fasting forever. Watch till the end to discover the most important rule of sustainable OMAD success. ⏱️ Time Stamps (21:04) 00:00 ⏰ Why most people ask the WRONG OMAD question 01:10 🧬 What makes OMAD powerful (fasting, insulin & fat burning) 02:20 🌞 Circadian rhythm explained simply 03:45 🔄 Hormones change throughout the day 05:00 🌅 Morning OMAD — metabolic advantages 06:50 🧠 Cortisol, digestion & energy in early eating 08:05 🔥 Autophagy and long overnight fasting 09:15 😣 Social stress & evening hunger challenges 10:30 🌤️ Afternoon OMAD — the balanced approach 12:05 ⚡ Energy stability & exercise timing benefits 13:20 🍽️ Why many people sustain afternoon OMAD best 14:40 🌙 Evening OMAD — social comfort vs metabolic trade-offs 16:00 💤 Sleep disruption & late meal effects 17:00 🧩 Chronotype, work schedule & lifestyle factors 18:15 🧪 2-Week OMAD testing method 19:40 📊 The 5 markers to track (energy, sleep, hunger, digestion, results) 20:30 🎯 The real secret — consistency over perfection OMAD timing, best time to eat OMAD, intermittent fasting schedule, circadian rhythm fasting, autophagy fasting benefits, fat loss fasting method, one meal a day results, metabolic health fasting, insulin sensitivity timing, fasting and hormones, fasting for weight loss, OMAD science explained, optimal meal timing, fasting lifestyle tips, metabolic flexibility fasting, morning vs evening OMAD, sustainable fasting routine, fasting energy optimization, sleep and fasting timing, advanced intermittent fasting #OMAD #IntermittentFasting #FastingScience #Autophagy #FatLoss #WeightLossTips #HealthyMetabolism #MealTiming #CircadianRhythm #OneMealADay #FastingLifestyle #MetabolicHealth #Longevity #HealthOptimization #BiohackingHealth #NutritionScience #SleepHealth #HormoneBalance #WellnessEducation #HealthyLiving 📚 References Research on circadian rhythm and metabolism Studies on insulin sensitivity variations across the day Intermittent fasting and metabolic flexibility research Autophagy and fasting duration studies Clinical observations in lifestyle medicine and nutrition timing ⚠️ Disclaimer: This video is for educational and informational purposes only and is not medical advice. Fasting may not be appropriate for everyone, especially individuals with medical conditions, metabolic disorders, pregnancy, or those taking medication. Always consult a qualified healthcare professional before making dietary or fasting changes.