Basophil erythroblast Or Basophilic erythroblast, early normoblast; Key Features, Developmental Path скачать в хорошем качестве

Basophil erythroblast Or Basophilic erythroblast, early normoblast; Key Features, Developmental Path

🩸 A basophilic erythroblast—also known as an early normoblast—is a key stage in the development of red blood cells during erythropoiesis. It follows the proerythroblast and precedes the polychromatophilic erythroblast in the erythroid lineage. 🔬 Key Features of Basophilic Erythroblasts Characteristic Description Size ~12–17 µm in diameter Nucleus Round, centrally located, with coarse chromatin and no visible nucleoli Cytoplasm Deeply basophilic (blue-purple) due to abundant ribosomal RNA Function Actively synthesizing hemoglobin Division Capable of mitosis—still proliferative 🧬 Why the Cytoplasm Is So Blue The intense basophilic staining is caused by: High concentrations of polyribosomes (RNA-rich) Active protein synthesis, especially of globin chains for hemoglobin 🔄 Position in Erythroid Maturation text Hematopoietic Stem Cell ↓ Common Myeloid Progenitor ↓ BFU-E → CFU-E ↓ Proerythroblast ↓ Basophilic Erythroblast (Early Normoblast) ↓ Polychromatophilic Erythroblast ↓ Orthochromatic Erythroblast ↓ Reticulocyte ↓ Mature Erythrocyte (RBC) 🧠 Clinical Relevance Seen in bone marrow smears, rarely in peripheral blood (unless pathology is present) Abnormalities in this stage may indicate ineffective erythropoiesis, such as in iron-deficiency anemia, megaloblastic anemia, or thalassemia #Basophil #erythroblast