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Enrol in the 9-Week Science of Thriving Course → https://scienceofthriving.com.au Follow us on Instagram → @tonyboutagy Listen on all platforms → 🎙️ Episode Summary In this episode, we’re joined by Dr. Lauren Colenso-Semple, a researcher whose work has fundamentally changed how we approach women’s training across the menstrual cycle. Lauren conducted the most tightly controlled human study to date on how hormonal fluctuations impact performance, fuel utilization, and muscle adaptation in women — offering the clearest counter to decades of flawed, male-biased or rodent-based assumptions. Her work was completed in one of the world’s most prestigious muscle protein synthesis labs and has major implications for resistance training, nutrition, and program design for active women and their coaches. ⏱️ Timestamps 00:00 – Menstrual Cycle & Hormonal Fluctuations 03:01 – Research Gaps in Female Physiology 06:02 – Hormonal Impact on Fuel Use 09:05 – Limitations of Rodent Data 11:56 – Gender Differences in Training Adaptations 14:58 – Endurance Training Considerations 17:46 – Cortisol, Stress & Recovery 20:46 – Muscle Adaptations Across the Cycle 24:07 – Fueling Strategies for Women 26:52 – Impact of Oral Contraceptives 28:13 – Performance Implications of the Pill 29:53 – Muscle Fiber Type Differences 36:04 – Female Muscle Hypertrophy 42:21 – Nutrition & Training Myths 48:52 – Supplements & Female Fitness 📚 Resources & Mentions Science of Thriving Course → https://scienceofthriving.com.au Follow Dr Lauren Colenso-Semple @drlaurencs1 Support the Show: If this episode brought you clarity, subscribe, share it with a coach or training partner, and leave a review to help more women train with confidence and evidence — not guesswork.