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Watch the Full Video at https://www.jove.com/v/57752/gait-ana.... Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration - a 2 minute Preview of the Experimental Protocol Christine M. Rostosky, Ira Milosevic European Neuroscience Institute (ENI),; University Medical Center Göttigen (UMG),; In this study, we demonstrate the use of kinematic gait analysis based on ventral plane imaging to monitor the subtle changes in motor coordination as well as the progression of neurodegeneration with advancing age in mouse models (e.g., endophilin mutant mouse lines). Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments