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A patient's leg turns black. But here's the paradox: The bacteria are spreading faster than the tissue is dying. Why? And what does it mean for treatment? Gangrene isn't just necrosis—it's a race between infection and tissue death. In this video, Dr. Osama Alsheikhi breaks down the pathophysiology that separates wet gangrene from dry gangrene, and why timing is everything. What You'll Learn: Pathophysiology: Why infection spreads faster than tissue death Wet vs. Dry Gangrene: Clinical differences and prognosis The role of anaerobic bacteria (Clostridium perfringens) Why amputation timing matters (Golden Window concept) High-yield for USMLE Step 2 CK & Surgery rotations Strategic Video Chapters 0:00 Introduction: What is an "Eating Sore"? 0:47 The Two Ingredients: Necrosis + Putrefaction 1:22 Dry Gangrene: Arterial Blockage & Demarcation Lines 2:05 The Chemistry of Black Tissue: Iron Sulfide 2:40 Wet Gangrene: Venous Obstruction & Diabetic Risks 3:38 Comparing Dry vs. Wet Gangrene 3:56 Gas Gangrene: Clostridium & The Telltale Crepitus 4:52 Summary: Three Causes, Three Outcomes #Surgery #Pathophysiology #MedicalEducation #ClinicalReasoning 🔔 Subscribe to MedCore Academy and turn on notifications to never miss a lecture. Have a specific topic you'd like to see covered? Let us know in the comments!