Wendy M Kohrt - Acute catabolic (yes, catabolic!) response of bone to exercise скачать в хорошем качестве

Wendy M Kohrt - Acute catabolic (yes, catabolic!) response of bone to exercise

Dr. Kohrt has been studying the influence of exercise training on the musculoskeletal system for 30 years. Early in her career, she observed that the ‘best’ exercisers did not necessarily have the ‘best’ skeletal adaptations to training, suggesting there were unknown mediators or moderators of the response. The overarching hypothesis for her work in this area in recent years is that the mechanical loading characteristics of exercise influence the anabolic response of bone, and that metabolic characteristics of exercise determine the catabolic response. Under this hypothesis, the net adaptation of bone to exercise training would reflect the opposing activation of both anabolic and catabolic pathways. She will present evidence that the disruption of calcium homeostasis during exercise generates a robust acute catabolic response in bone that is mediated by parathyroid hormone and discuss factors that modify this response.