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Enduring Activity: 2021 Pediatric Grand Rounds “The 47th Annual Dr. John I. Perlstein Memorial Lectureship: The Odyssey of Therapeutic Discovery: Antiviral Drug Development Programs” Target Audience This activity is targeted toward all general pediatric physicians and pediatric subspecialists in the community. Statement of Need Pediatric grand rounds provide physicians a continuous update on emerging trends in caring for the pediatric patient, including new scientific discoveries that provide the underpinning of current pediatric practice. This activity will inform physicians about other issues involving professionalism, socioeconomic issues, and topics related to the ACMGE core competencies. Objectives At the conclusion of this offering, the participant will be able to: 1. Identify different classes of antiviral drugs. 2. Discuss the appropriate initiation of different antiviral agents in clinical practice. 3. Evaluate the clinical effectiveness of antiviral therapies. 4. Review the development of antiviral resistance as a function of antiviral use.. Faculty David Kimberlin, MD Professor of Pediatrics Vice Chair for Clinical and Translational Research Department of Pediatrics University of Alabama at Birmingham Faculty Disclosure Faculty for this course has no conflicts of interest to disclose. Planner Disclosure No planners for this course have conflicts of interest to disclose. Accreditation This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Norton Healthcare and the University of Louisville Department Of Pediatrics. Norton Healthcare is accredited by the Kentucky Medical Association to provide continuing medical education for physicians. Designation Norton Healthcare designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Date of Original Release | November 2021 Course Termination Date | November 2023 Contact Information | Center for Continuing Medical Education; (502) 446-5955 or [email protected] Resources Neonatal herpes simplex virus infections https://pubmed.ncbi.nlm.nih.gov/29544... Preventing herpes simplex virus in the newborn https://pubmed.ncbi.nlm.nih.gov/25459... Antiviral Drugs in Newborn and Children https://pubmed.ncbi.nlm.nih.gov/29173... Compassionate use of Remdesivir in children with COVID-19 https://pubmed.ncbi.nlm.nih.gov/33200...