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Inflammatory Bowel Disease (IBD) — UC vs Crohn's | Disease Management Series | Med School Content A complete breakdown of Inflammatory Bowel Disease for medical students and Step prep — from pathophysiology to pharmacology, with board-testable pearls throughout. 📌 Topics Covered: • IBD overview — two diseases, one autoimmune umbrella • Pathophysiology — UC (superficial, continuous) vs CD (transmural, skip lesions) • Clinical presentation — bloody diarrhea vs RLQ pain, perianal disease, malabsorption cascade • Extraintestinal manifestations — arthritis, erythema nodosum, pyoderma gangrenosum, uveitis, PSC • Diagnosis & workup — fecal calprotectin, colonoscopy timing, endoscopic findings • UC management — 5-ASA, steroids (induction only), biologics, acute severe UC protocol • CD management — step-up vs top-down, fistulizing CD, surgical indications • Complications — toxic megacolon, strictures, fistulas, CRC surveillance • Pharmacology pearls — sulfasalazine mechanism, oligospermia, TPMT testing, anti-IL-17 contraindication, pregnancy safety 📚 Sources & References: • Harrison's Principles of Internal Medicine, 22nd Edition — Chapter 337 (pp. 2594–2612) • AGA Clinical Practice Guideline on the Management of Moderate to Severe Ulcerative Colitis (2024) — PMID: 39572132 • ACG Clinical Guideline on the Management of Crohn's Disease in Adults (2025) — PMID: 40701562 • AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of IBD (2023) — PMID: 36822736 🎯 High-yield for USMLE Step 1 and Step 2 CK — covers pathophysiology, clinical diagnosis, pharmacology mechanisms, and management algorithms. ⚠️ Disclaimer: This video is for educational purposes only and does not constitute medical advice. All patients should consult with their healthcare providers about any health concerns. #IBD #InflammatoryBowelDisease #UlcerativeColitis #CrohnsDisease #USMLE #Step1 #Step2CK #GastroenterologyMedEd #MedSchoolContent #DiseaseManagement #BoardReview