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Disease is a condition in which the normal structure or function of the body is disturbed, producing specific signs and symptoms. It may affect one organ, a system, or the whole body. Diseases can be caused by infections, genetic factors, lifestyle habits, nutritional deficiencies, environmental exposure, or immune system problems. Common features of disease include pain, fever, weakness, inflammation, and functional impairment. Diagnosis is done through history taking, physical examination, and investigations such as blood tests, imaging, and other diagnostic procedures. Management of disease includes prevention, early detection, medical treatment, nursing care, lifestyle modification, and patient education. The main goal is to reduce complications, improve quality of life, and promote recovery.