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Are you observing elevated homocysteine levels despite making diet changes? In this video, we'll explore the impact of diet on high homocysteine. We'll delve into foods with the highest homocysteine levels, examine relevant research, and understand the importance of ensuring an adequate intake of B12 and folate when addressing this concern. References: https://fdc.nal.usda.gov/ https://www.sciencedirect.com/science... https://www.sciencedirect.com/science.... I recently received a question from a viewer about his homocysteine levels. Initially, it was 13.7 micromoles per liter. After adopting a carnivore diet with plenty of red meat, it increased to 26.9 micromoles per liter. So, what could be the reason? While this question is quite straightforward, I wanted to double-check that I wasn't missing anything and delved into the methionine sources of different proteins and various foods in general. As mentioned in previous videos, animal protein is rich in methionine. For example, per 100 grams, whole eggs provide around 0.9 grams of methionine, while fish sources like tuna and yellowfin might have 0.7 grams of methionine per 100 grams. Turkey, chicken, and beef contain slightly less. Plant sources, such as dark leafy greens, beans, or lentils, have significantly lower levels of methionine compared to animal sources. You can explore further details on this by checking the link in the description. If someone primarily consumes meat or fish, their methionine levels are likely to increase. Methionine converts into SAMe, which then transforms into S adenosylhomocysteine, eventually leading to homocysteine. With sufficient B12 and folate levels, this conversion should occur without issues. However, if deficient in either, homocysteine accumulates. The more methionine consumed, the higher the homocysteine levels. An analogy is like a river with a dam and a small release valve. Increased methionine is like rain raising the river levels. To address this, widening the release valve, or increasing B12 and folate levels, is necessary. Despite B12 being abundant in animal products, this person might not be absorbing it properly or could be low in folate. Difficulty converting folate into methylfolate, especially with MTHFR genetic alterations, is also a possibility. Let's consider the research on this matter. Observational studies, like one in Pakistan involving 872 healthy adults, found that diets higher in fruit and uncooked vegetables correlated with lower homocysteine levels. In contrast, diets with more chicken, red meat, and milk were associated with higher homocysteine levels. Another study in China indicated that a cereal-based diet with lower vitamin intake resulted in higher homocysteine levels. In summary, ensuring sufficient B12 and folate levels is crucial in addressing elevated homocysteine due to dietary choices. B6 may also be important in some cases. Homocysteine is highly responsive to these B vitamins, and addressing deficiencies should lead to normalized levels. Even with a high meat or fish intake, as long as B vitamins are adequate, homocysteine levels should remain normal. Have you experimented with elevated homocysteine levels and taking B vitamins? Have you faced challenges with homocysteine levels during diet changes? Checking your B vitamin status could provide a better understanding of the situation