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People with sickle cell disease often deal with serious pain—both sudden pain episodes and long-term, ongoing pain. This kind of pain is complex and sometimes overlooked. In this upcoming lecture, Dr. Jeffrey Weisman gave a clear overview of how to manage pain in this group, including: •What causes sudden (vaso-occlusive) and chronic pain in sickle cell disease •How to safely use opioids and other treatments backed by research •How team-based care can improve daily life and health outcomes 0:00 – Introduction & Overview Welcome, July greetings, and overview of the talk: sickle cell disease, types of pain, and management approaches. 1:08 – What is Sickle Cell Disease? Explanation of the disease, red blood cell changes, and impact on the body. 3:21 – Visualizing Sickle Cells Illustration of normal vs. sickled blood cells and how blockages occur. 4:06 – Who is Affected? Epidemiology, prevalence in the U.S. and worldwide, and relevance to diverse audiences. 5:56 – Genetics & Inheritance How sickle cell disease and trait are inherited, differences between carriers and affected individuals. 8:20 – Symptoms of Sickle Cell Disease Range of symptoms: anemia, jaundice, pain crises, organ involvement, and more. 9:35 – Diagnosing Sickle Cell Disease Blood tests, prenatal screening, newborn screening, and confirmation procedures. 12:53 – Pain in Sickle Cell Disease Types of pain, mechanisms, chronic vs. acute pain, and central sensitization. 15:47 – Optimizing Pain Management & Team Approach Importance of a multi-disciplinary care team, integrative treatment, and biocpsychosocial approach. 23:24 – Mindfulness, CBT & Resources Cognitive behavioral therapy, mindfulness meditation, apps, books, and community/pain research resources. Stanford Division of Pain Medicine https://med.stanford.edu/pain.html Stanford Pain Medicine on Facebook: / stanfordpainmedicine Stanford Pain Medicine on Instagram: / stanford.pain Stanford Pain Medicine on Twitter: / stanfordpain