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Welcome to the Creative Commons Rx Podcast! Before diving into this episode, I want to ensure we're all on the same page. This is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient or pharmacist-patient relationship is formed. Using this information and the materials linked to this podcast is at the user's risk. The content on this podcast is not intended to substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice from any medical condition they have, and they should seek the assistance of their health care professionals for any such conditions. Clinical experts created the references, content, and clinical insight. NotebookLM, a Google AI tool, created the audio content, which I extensively reviewed before release. Finally, the host states that he takes all conflicts of interest seriously. Currently, there are no conflicts to disclose. For all of his disclosures and the companies he invests in or advises, he directs users to reach out independently, where he keeps an up-to-date and active list of all disclosures. Welcome to a deep dive into Occupational Exposure Toxicology! This is a vital topic for emergency medicine and healthcare providers, as recognizing these work-related chemical exposures is paramount for appropriate patient management and preventing further incidents. This curriculum explores the essential intersection of toxicology and emergency response. We highlight why healthcare facilities must be prepared to manage patients who are contaminated with chemical, biological, or radiological agents, even if they present directly to the hospital without prior field decontamination. Decontamination is essential not only to prevent further absorption by the victim but also to prevent secondary contamination of staff and equipment, and ultimately, to prevent the closure of the facility. We review the significant regulatory requirements from bodies like the Joint Commission and OSHA, emphasizing that medical personnel involved in decontamination must be trained to the First Responder Operations Level and are operating as specialized occupational responders. Clinically, diagnosing these issues often hinges on obtaining a thorough occupational history. We delve into the broad range of toxic syndromes that affect nearly every organ system—from acute irritant inhalation injury, inhalational fevers, and occupational asthma, to systemic disorders impacting the cardiovascular, hepatic, renal, and nervous systems. Remember two critical principles: the predominant exposure pathway for serious injury is airborne exposure via inhalation, and every poisoned worker should be considered an 'index case,' demanding immediate investigation to prevent co-worker exposure. We also examine high-stakes scenarios, such as sudden collapse or cardiopulmonary arrest in a confined space, which warrants immediate high suspicion for toxic gases like carbon monoxide (CO) or hydrogen sulfide (H₂S) or oxygen deficiency. The cornerstone of patient management remains the elimination or reduction of further exposure to the toxin, often achieved through consultation with a regional poison control center for specific antidotes or therapies. Tune in to boost your preparedness and patient safety knowledge regarding the critically poisoned worker!