Bioengineering - Treating cancer with engineered microbes скачать в хорошем качестве

Bioengineering - Treating cancer with engineered microbes

Subscribe:    / @everycellauniverse   Twitter:   / everycellauni   EVERY CELL A UNIVERSE is my new YouTube channel dedicated to the wonders of the microscopic natural world. I explore how life works and what we can do with this knowledge. Bacteria can be engineered to treat cancers. One key bacterial candidate scientists are trying to beat cancer with are salmonella bacteria. In this video I describe one experimental approach which is effective against cancer cells grown in the lab. Some engineered bacteria have been tested in human trials against cancer, but so far they haven’t been successful. Nonetheless these methods are interesting and could provide a safe and effective way to battle cancer in the future. That’s why there is lots of interest to research the subject. -- Recommended reading Ed Yong’s fantastic book on the microbiome. No affiliate link. I don’t get anything if you buy the book through the link. http://a.co/eS5nsTD -- Resources The original article by Eva Camacho and colleagues Camacho, E. M., Mesa-Pereira, B., Medina, C., Flores, A., & Santero, E. (2016). Engineering Salmonella as intracellular factory for effective killing of tumour cells. Scientific Reports, 6(1), 30591. https://doi.org/10.1038/srep30591 Using bacteria against bladder cancer Gandhi, N. M., Morales, A., & Lamm, D. L. (2013). Bacillus Calmette-Guérin immunotherapy for genitourinary cancer. BJU International, 112(3), 288–297. https://doi.org/10.1111/j.1464-410X.2... Review article on bacteria to treat cancer. Summarizes the mouse and human trials done on the subject. Humans trials haven’t been successful, but mouse trials have been. Nallar, S. C., Xu, D.-Q., & Kalvakolanu, D. V. (2017). Bacteria and genetically modified bacteria as cancer therapeutics: Current advances and challenges. Cytokine, 89, 160–172. https://doi.org/10.1016/j.cyto.2016.0... -- Credits Cell images in channel intro adapted from photos by: Howard Vindin CC BY-SA 4.0 National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) CC BY 2.0 National Institutes of Health (NIH) Salmonella - NIAID Macrophage adapted from photo by Dr. Timothy Triche, NIH