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In this episode, Dr. Mitchell Elkind, a top neurologist and chief clinical science officer at the American Heart Association, discusses cutting-edge strategies in stroke prevention and cerebrovascular health research. He guides listeners through the core causes of strokes and then explores innovative approaches to risk prediction and reduction, highlighting the potential of screening for atrial cardiopathy. Dr. Elkind also shares insights from his research on inflammatory and infectious biomarkers, offering a glimpse into the future of stroke prevention. Dr. Elkind emphasizes the critical role of preventive care and public health measures in reducing stroke incidence globally, providing a comprehensive view of current advancements and future directions in cerebrovascular medicine. Note: This lecture was recorded in November 2022. Learn more about Dr. Mitchell Elkind’s work: https://www.neurology.columbia.edu/pr... Learn more about Dr. David Dodick: https://www.atria.org/doctors/dr-davi... Time stamps: 00:00:15: Intro 00:03:00: Dr. Mitchell Elkind 00:05:28: The importance of studying the human brain 00:06:33: Learning about how the brain works through strokes and other brain injuries 00:08:33: Strokes and understanding a person’s ability to function 00:09:14: The Homunculus: representing parts of the body controlled by the brain00:10:01: Importance of a patient’s history and neurological exams in diagnosis 00:11:3216: Introduction to cryptogenic stroke 00:12:20: Stroke rates in the US are rising and have racial and geographic disparities 00:14:44: Understanding cryptogenic stroke 00:19:07: Defining what counts as an embolic stroke of undetermined source (ESUS) 00:21:00: Evidence for unexplained strokes being emboli 00:22:33: The challenges of preventing ESUS 00:24:37: Potential causes of embolic strokes of undetermined source 00:25:19: Atrial cardiopathy and the role of infection in causing strokes 00:33:00: Revisiting the traditional concept of atrial fibrillation as a mechanism of stroke 00:42:00: Anticoagulant trials and the effect of new medications on stroke patients 00:47:00: Relationship between infection and atherosclerosis 00:50:23: Infectious burden and risk of stroke 00:52:21: The impact of acute infections on stroke 00:53:16: Investigating why a stroke occurs on a specific day 00:59:30: Association of herpes virus infection and stroke in kids 01:00:56: COVID-19’s impact on stroke 01:04:33: Concept of a vulnerable time period 01:05:15: Therapeutic implications of the relationship between infection and stroke — About: Atria’s Vanguard Symposia is a lecture series where some of the world’s most compelling researchers translate leading-edge science into medicine. In each episode, top experts share breakthrough science about preventive health care, dive deep into headline-grabbing topics, and take you beyond the buzzwords to explain the latest in longevity science. Our show will arm you with practical information and the tools of discernment to cut through the hype and understand what matters most. Atria Health and Research Institute aims to accelerate a global shift from reactive sick care to proactive, preventive health care. We work at the forefront of science and technology and we believe a collaborative approach to modern medicine can extend healthy life for all. Learn more: https://www.atria.org/ Subscribe to Atria’s Vanguard Symposia on: Apple Podcasts: https://bit.ly/AtriaVanguardApplePodc... Spotify: https://bit.ly/AtriaVanguardSpotify Sign up for our newsletter: https://bit.ly/Atria-Newsletter The information contained in this podcast is for general informational and educational purposes only and does not constitute or serve as a substitute for professional medical advice, treatment, or diagnosis. Always consult the advice of your personal health care provider when seeking medical advice for any condition you may have, and never delay treatment or disregard advice from a professional health care provider based on something you have seen or heard in this content. No part of this podcast can be reproduced, redistributed, published, copied or duplicated in any form without the prior written permission of Atria.