Classic Psychedelics: What are they, how do they work? скачать в хорошем качестве

Classic Psychedelics: What are they, how do they work?

Professor Robin Carhart-Harris for the Mind, Technology, and Society (MTS) Talk series on April 24, 2023. This talk takes a multi-level view of the brain action of classic psychedelic drugs, i.e., drugs that share the property of activating the serotonin 2A receptor. Beginning at the receptor level, it moves through a developmental and evolutionary understanding of serotonergic functioning and brain plasticity, placing emphasis on the context dependency of responses to classic psychedelic compounds. It reviews the dynamic, whole-brain action of psychedelics and how this relates to knowledge of the development and evolution of global brain function and anatomy. It couches our understanding of the therapeutic action of psychedelic therapy within a predictive coding framework and reviews recent trial and imaging results from a double-blind randomized controlled trial of psilocybin therapy vs escitalopram for depression.