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340 Pounds Down with Zepbound! Jamie Tells the Truth About GLP-1s Downsized Dish with Jamie Selzler – How He Lost 340 Pounds on Zepbound In this episode of The Downsized Dish, Christopher Durham sits down with Selzler, who shares how he lost 340 pounds using the GLP-1 medication Zepbound. Jamie opens up about his experience starting at 652 pounds, the emotional and physical toll of living with severe obesity, and the mindset that helped him transform his life. Filmed in Annapolis, Virginia, during the Your Weight Matters National Convention hosted by the Obesity Action Coalition, this is one of the most honest and inspiring conversations we’ve had. Jamie talks about how he started his GLP-1 treatment with Wegovy, transitioned to Zepbound due to shortages, and has stayed on the medication for nearly two years. Christopher and Jamie cover everything from food noise, and self-discipline to the toxic expectations of diet culture. Jamie explains why exercise wasn't possible at first and how he slowly rebuilt mobility over time. He also shares how he’s shifted his focus from goal weight to input goals like hydration, movement, and consistency. Topics include: • Why it took three months to see results on GLP-1 medication • What to expect with side effects like constipation, fatigue, and food sensitivity • How to keep promises to yourself and build momentum • The power of non-scale victories • Why motivation fades and consistency matters more • Jamie’s plan to hike 20 miles by the end of the year This is a must-watch for anyone treating obesity with GLP-1s or thinking about starting. Jamie brings clarity, encouragement, and practical advice for real people facing real struggles. Follow Jamie on social media and reach out if you need support. His message is simple and powerful: You are not alone, and you deserve a better life. FOLLOW JAMIE: YOUTUBE: @jselzler TikTok: @jamselz IG: @jselzler DOWNSIZED LINKS: Shop our GLP-1 companion products: https://thedownsized.org/downsized-store Visit our website: https://thedownsized.org/ Join us for the Downsized at Sea Cruise 2026: https://thedownsized.org/downsized-at... Become a channel member and unlock exclusive perks: / @thedownsized For sponsorships, brand deals, and press inquiries: https://thedownsized.org/contact/ 00:00 Introduction and Welcome 00:11 Meet Jamie: A Special Guest 00:45 Disclaimer and Social Media Plugs 01:50 Jamie's Weight Loss Journey 02:08 The Role of GLP-1 Medication 02:30 Challenges and Public Speaking 03:04 Mind Pump Podcast Appearance 04:56 Life Changes and Non-Scale Victories 11:33 Exercise and Mobility 17:53 Mindset and Motivation 27:48 Setting Achievable Input Goals 30:52 The Importance of Self-Compassion 32:43 The Journey to Weight Loss 35:07 The Role of GLP-1 Medication 37:04 Managing Side Effects 40:24 Personal Experiences and Advice 42:56 The Emotional Impact of Weight Loss 48:59 Future Goals and Reflections 52:32 Final Thoughts and Encouragement