In suspected Creutzfeldt-Jakob Disease, when should CSF 14-3-3 testing be performed? скачать в хорошем качестве

In suspected Creutzfeldt-Jakob Disease, when should CSF 14-3-3 testing be performed?

In adults with rapidly progressive dementia and suspected Creutzfeldt-Jakob Disease, clinicians must decide when to obtain cerebrospinal fluid 14-3-3 protein testing. The key question is whether to order this test early alongside MRI and EEG, or to reserve it for cases in which initial studies are inconclusive. Ordering it too early can reduce specificity and increase false positives, leading to unnecessary lumbar puncture and diagnostic confusion. The discussed framework prioritizes MRI and EEG first, using 14-3-3 testing selectively when uncertainty persists or suspicion remains high. This sequencing strategy aims to balance diagnostic accuracy with procedural risk in a time-sensitive neurodegenerative presentation. #Neurology #CreutzfeldtJakobDisease #Dementia #ClinicalDecisionMaking