Nanoparticle-assisted NMR relaxation in protein dynamics & metabolomics | Dr. Mouzhe Xie |Session 18 скачать в хорошем качестве

Nanoparticle-assisted NMR relaxation in protein dynamics & metabolomics | Dr. Mouzhe Xie |Session 18

The 18th session of the Global NMR Discussion Meeting was held on 10th November 2020 via Zoom. Dr. Mouzhe Xie gave a talk on nanoparticle-assisted nuclear magnetic resonance (NMR) relaxation in protein dynamics and metabolomics. The video was recorded live during the presentation and serves as an educative lecture. Bio: Mouzhe Xie studied chemical biology at Xiamen University (China) from 2009-2013. He received his Ph.D. degree from The Ohio State University (USA) in 2018, where he developed and applied solution NMR spectroscopy to study protein dynamics and metabolomics. He then spent 5 months at EPFL (Switzerland) as a visiting scientist. Currently, he is conducting postdoctoral research on nanoscale NMR and quantum sensing at the University of Chicago (USA). Personal website: https://sites.google.com/view/xiemouzhe Google scholar: https://scholar.google.com/citations?... LinkedIn:   / mouzhe-xie-76187857   Abstract: In nanoparticle-assisted solution NMR, synthetic nanoparticles are added to NMR samples, which reduce the reorientational motion of molecules or protein regions in a selective or differential way. This leads to interesting spectral observations that contain critical information about the physicochemical properties, structures, dynamics, and functions of biomolecules. In this tutorial, I will introduce the basics of NMR relaxation theories, followed by some technical details including pulse selection and data processing. The discussion will be buttressed by recent studies on some important topics, such as supra-τc (slow) internal motions of globular proteins, cooperative binding of intrinsically disordered proteins to inorganic surfaces, and accurate metabolite identification in the context of NMR-based metabolomics." Organizing committee: Adrian Draney (Guido Pintacuda Lab, CRMN Lyon, France) Amrit Venkatesh (Aaron Rossini Lab, Iowa State University, USA) Asif Equbal (Songi Han Lab, UCSB, USA) Blake Wilson (Robert Tycko Lab, NIH, USA) Michael Hope (Lyndon Emsley Lab, EPFL, Switzerland) Pinelopi Moutzouri (Lyndon Emsley Lab, EPFL, Switzerland)